Continuing the story of the film before, this time Larry Daley has become a successful businessman.

Until when he visited a museum where he worked before, and found the museum will be undergoing renovation, and his "friends" will be sent to other museums in the storage room.

Accidentally, the tablet is stolen by little monkey and brough to the Smithsonian Institution, where all the museum inhabitant will take they new place.The adventure began when Larry found that Kahmunrah, one of the museum figures is trying to claim the tablet in order to open the gate and raise his army from the death. Prevent the tablet fall into Kahmunrah hand, Larry helped by his new "friends", make the story funnier, and there are many new figures that are not found in the first movie, Amelia Earhart (Adams), women who make the flight across the Atlantic alone, George Armstrong Custer (Hader), civil war figures, Al Capone (Bernthal), one of biggest mafia, Napoleon Bonaparte (Chabat), and Albert Einstein (Levy).

Larry and his new "friends" set to mission to capture the tablet from Kahmunrah before sunrise and put the museum inhabitant back to museum or they will burn by sun.

This movie is selling "Stiller" comedy, but unfortunatelly in some schene Adams seems little bit too much, since her character is set to be attractive. In general, this movie is very entertaining, make people laugh and bring interest to people to visit the museum, just like the first movie.